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ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma - Cell Death Discovery

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ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma - Cell Death Discovery

Zinc finger protein 281 (ZNF281) has been shown to promote tumor progression. However, the underlying mechanism remains to be further elucidated. In this study, ZNF281 knockdown increased the expression of mitochondrial transcription factor A (TFAM) in hepatocellular carcinoma (HCC) cells, accompanied with increment of mitochondrial content, oxygen consumption rate (OCR) and levels of TCA cycle intermetabolites.

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ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma - Cell Death Discovery

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ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma - Cell Death Discovery

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