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Mechanisms of action and resistance in histone methylation-targeted therapy - Nature

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Mechanisms of action and resistance in histone methylation-targeted therapy - Nature

Epigenomes enable the rectification of disordered cancer gene expression, thereby providing new targets for pharmacological interventions. The clinical utility of targeting histone H3 lysine trimethylation (H3K27me3) as an epigenetic hallmark has been demonstrated1–7. However, in actual therapeutic settings, the mechanism by which H3K27me3-targeting therapies exert their effects and the response of tumour cells remain unclear.

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Mechanisms of action and resistance in histone methylation-targeted therapy - Nature

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Mechanisms of action and resistance in histone methylation-targeted therapy - Nature

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