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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation - Nature Reviews Molecular Cell Biology

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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation - Nature Reviews Molecular Cell Biology

The primary regulators of metazoan gene expression are enhancers, originally functionally defined as DNA sequences that can activate transcription at promoters in an orientation-independent and distance-independent manner. Despite being crucial for gene regulation in animals, what mechanisms underlie enhancer selectivity for promoters, and more fundamentally, how enhancers interact with promoters and activate transcription, remain poorly understood.

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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation - Nature Reviews Molecular Cell Biology

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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation - Nature Reviews Molecular Cell Biology

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