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Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition - Nature Structural & Molecular Biology

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Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition - Nature Structural & Molecular Biology

Gene expression during natural and induced reprogramming is controlled by pioneer transcription factors that initiate transcription from closed chromatin. Nr5a2 is a key pioneer factor that regulates zygotic genome activation in totipotent embryos, pluripotency in embryonic stem cells and metabolism in adult tissues, but the mechanism of its pioneer activity remains poorly understood. Here, we present a cryo-electron microscopy structure of human NR5A2 bound to a nucleosome.

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Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition - Nature Structural & Molecular Biology

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Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition - Nature Structural & Molecular Biology

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