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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels - Nature Cell Biology

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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels - Nature Cell Biology

Cells sense physical forces and convert them into electrical or chemical signals, a process known as mechanotransduction. Whereas extensive studies focus on mechanotransduction at the plasma membrane, little is known about whether and how intracellular organelles sense mechanical force and the physiological functions of organellar mechanosensing. Here we identify the Drosophila TMEM63 (DmTMEM63) ion channel as an intrinsic mechanosensor of the lysosome, a major degradative organelle.

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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels - Nature Cell Biology

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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels - Nature Cell Biology

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