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Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase - Nature Catalysis

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Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase - Nature Catalysis

Epistasis, the non-additive effect of mutations, can provide combinatorial improvements to enzyme activity that substantially exceed the gains from individual mutations. Yet the molecular mechanisms of epistasis remain elusive, undermining our ability to predict pathogen evolution and engineer biocatalysts. Here we reveal how directed evolution of a β-lactamase yielded highly epistatic activity enhancements.

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Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase - Nature Catalysis

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Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase - Nature Catalysis

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