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Nickel-electrocatalysed C(sp3)–C(sp3) cross-coupling of unactivated alkyl halides - Nature Catalysis

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Nickel-electrocatalysed C(sp3)–C(sp3) cross-coupling of unactivated alkyl halides - Nature Catalysis

The C(sp3)–C(sp3) linkages are undoubtedly important in natural products, pharmaceuticals and organic compounds. Electrochemical cross-electrophile coupling with a broad range of available alkyl halides is an attractive and useful strategy for the construction of C(sp3)–C(sp3) bonds, although success could only be seen on activated alkyl halides in previous reports, due to the great challenge of reactivity and selectivity control of unactivated alkyl halides.

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Nickel-electrocatalysed C(sp3)–C(sp3) cross-coupling of unactivated alkyl halides - Nature Catalysis

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Nickel-electrocatalysed C(sp3)–C(sp3) cross-coupling of unactivated alkyl halides - Nature Catalysis

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