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Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system - Nature Aging

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Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system - Nature Aging

Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are unclear. Here we show that activation of S6K specifically in Drosophila fat-body blocked extension of lifespan by rapamycin, induced accumulation of multilamellar lysosomes and blocked age-associated hyperactivation of the NF-κB-like immune deficiency (IMD) pathway, indicative of reduced inflammaging.

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Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system - Nature Aging

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Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system - Nature Aging

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