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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences - Nature Microbiology

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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences - Nature Microbiology

The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candidalysin and seven non-candidalysin Ece1 peptides (NCEPs), and is found to be conserved in clinical isolates. Here we show that the Ece1 polyprotein does not resemble the usual precursor structure of peptide toxins.

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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences - Nature Microbiology

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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences - Nature Microbiology

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