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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis - Nature Immunology

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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis - Nature Immunology

Fibroblasts are important regulators of inflammation, but whether fibroblasts change phenotype during resolution of inflammation is not clear. Here we use positron emission tomography to detect fibroblast activation protein (FAP) as a means to visualize fibroblast activation in vivo during inflammation in humans. While tracer accumulation is high in active arthritis, it decreases after tumor necrosis factor and interleukin-17A inhibition.

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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis - Nature Immunology

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CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis - Nature Immunology

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