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PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis - Cell Death & Disease

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PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis - Cell Death & Disease

Many types of cancer cells, including colorectal cancer cells (CRC), can simultaneously enhance glycolysis and repress the mitochondrial tricarboxylic acid (TCA) cycle, which is called the Warburg effect. However, the detailed mechanisms of abnormal activation of the glycolysis pathway in colorectal cancer are largely unknown. In this study, we reveal that the protein arginine methyltransferase 1 (PRMT1) promotes glycolysis, proliferation, and tumorigenesis in CRC cells.

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PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis - Cell Death & Disease

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PRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis - Cell Death & Disease

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