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Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination - Oncogenesis

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Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination - Oncogenesis

Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [1, 2]. Since then, the 'Warburg effect' has been widely accepted as a key feature of rapidly proliferating cancer cells [3–5]. What is not clear is how early “Warburg metabolism” initiates in cancer and whether changes in energy metabolism might influence tumour progression ab initio.

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Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination - Oncogenesis

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Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination - Oncogenesis

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