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In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression - Communications Biology

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In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression - Communications Biology

Reduced inhibition by somatostatin-expressing interneurons is associated with depression. Administration of positive allosteric modulators of α5 subunit-containing GABAA receptor (α5-PAM) that selectively target this lost inhibition exhibit antidepressant and pro-cognitive effects in rodent models of chronic stress. However, the functional effects of α5-PAM on the human brain in vivo are unknown, and currently cannot be assessed experimentally.

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In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression - Communications Biology

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In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression - Communications Biology

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