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Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells - Nature Communications

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Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells - Nature Communications

Cardiac fibroblasts play an essential role in the development of the heart and are implicated in disease progression in the context of fibrosis and regeneration. Here, we establish a simple organoid culture platform using human pluripotent stem cell-derived epicardial cells and ventricular cardiomyocytes to study the development, maturation, and heterogeneity of cardiac fibroblasts under normal conditions and following treatment with pathological stimuli.

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Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells - Nature Communications

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Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells - Nature Communications

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