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Alternative Wnt-signaling axis leads to a break of oncogene-induced senescence - Cell Death & Disease

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Alternative Wnt-signaling axis leads to a break of oncogene-induced senescence - Cell Death & Disease

Oncogene-induced senescence (OIS) is an important process that suppresses tumor development, but the molecular mechanisms of OIS are still under investigation. It is known that BRAFV600E-mutated melanocytes can overcome OIS and develop melanoma, but the underlying mechanism is largely unknown. Using an established OIS model of primary melanocytes transduced with BRAFV600E, YAP activity was shown to be induced in OIS as well as in melanoma cells compared to that in normal epidermal melanocytes.

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Alternative Wnt-signaling axis leads to a break of oncogene-induced senescence - Cell Death & Disease

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