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Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish - npj Regenerative Medicine

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Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish - npj Regenerative Medicine

Skeletal muscles can regenerate after minor injuries, but severe structural damage often leads to fibrosis in mammals. Whether adult zebrafish possess the capacity to reproduce profoundly destroyed musculature remains unknown. Here, a new cryoinjury model revealed that several myomeres efficiently regenerated within one month after wounding the zebrafish caudal peduncle. Wound clearance involved accumulation of the selective autophagy receptor p62, an immune response and Collagen XII deposition.

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Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish - npj Regenerative Medicine

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Skeletal muscle regeneration after extensive cryoinjury of caudal myomeres in adult zebrafish - npj Regenerative Medicine

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