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Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function - Communications Biology

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Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function - Communications Biology

Skeletal muscle stem cells (MuSC) are crucial for tissue homoeostasis and repair after injury. Following activation, they proliferate to generate differentiating myoblasts. A proportion of cells self-renew, re-enter the MuSC niche under the basal lamina outside the myofiber and become quiescent. Quiescent MuSC have a primary cilium, which is disassembled upon cell cycle entry.

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Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function - Communications Biology

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Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function - Communications Biology

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