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MCT1 helps brown fat suck up succinate - Nature Metabolism

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MCT1 helps brown fat suck up succinate - Nature Metabolism

Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

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MCT1 helps brown fat suck up succinate - Nature Metabolism

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MCT1 helps brown fat suck up succinate - Nature Metabolism

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