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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes - Nature Metabolism

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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes - Nature Metabolism

Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that facilitate succinate uptake in these adipocytes remain undefined. Here we elucidate a mechanism underlying succinate import into BAT via monocarboxylate transporters (MCTs).

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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes - Nature Metabolism

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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes - Nature Metabolism

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