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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism - Nature Metabolism

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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism - Nature Metabolism

Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-expressing neurons reciprocally regulate food intake. Here, we combine non-interacting recombinases to simultaneously express functionally opposing chemogenetic receptors in AgRP and POMC neurons for comparing metabolic responses in male and female mice with simultaneous activation of AgRP and inhibition of POMC neurons with isolated activation of AgRP neurons or isolated inhibition of POMC neurons.

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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism - Nature Metabolism

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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism - Nature Metabolism

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