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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses - Nature Chemical Biology

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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses - Nature Chemical Biology

Major depressive disorder, a prevalent and severe psychiatric condition, necessitates development of new and fast-acting antidepressants. Genetic suppression of astrocytic inwardly rectifying potassium channel 4.1 (Kir4.1) in the lateral habenula ameliorates depression-like phenotypes in mice. However, Kir4.1 remains an elusive drug target for depression. Here, we discovered a series of Kir4.1 inhibitors through high-throughput screening.

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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses - Nature Chemical Biology

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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses - Nature Chemical Biology

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