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Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice - Nature Microbiology

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Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice - Nature Microbiology

In sub-Saharan Africa, multidrug-resistant non-typhoidal Salmonella serovars are a common cause of fatal bloodstream infection. Malnutrition is a predisposing factor, but the underlying mechanisms are unknown. Here we show that vitamin A deficiency, one of the most prevalent micronutrient deficits afflicting African children, increases susceptibility to disseminated non-typhoidal Salmonella disease in mice and impairs terminal neutrophil maturation.

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Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice - Nature Microbiology

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Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice - Nature Microbiology

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