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Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R - Nature Communications

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Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R - Nature Communications

Overfeeding triggers homeostatic compensatory mechanisms that counteract weight gain. Here, we show that both lean and diet-induced obese (DIO) male mice exhibit a potent and prolonged inhibition of voluntary food intake following overfeeding-induced weight gain. We reveal that FGF21 is dispensable for this defense against weight gain. Targeted proteomics unveiled novel circulating factors linked to overfeeding, including the protease legumain (LGMN).

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Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R - Nature Communications

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Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R - Nature Communications

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