Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution - Nature Structural & Molecular Biology

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Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution - Nature Structural & Molecular Biology

Shortening of messenger RNA poly(A) tails, or deadenylation, is a rate-limiting step in mRNA decay and is highly regulated during gene expression. The incorporation of non-adenosines in poly(A) tails, or 'mixed tailing', has been observed in vertebrates and viruses. Here, to quantitate the effect of mixed tails, we mathematically modeled deadenylation reactions at single-nucleotide resolution using an in vitro deadenylation system reconstituted with the complete human CCR4–NOT complex.

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Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution - Nature Structural & Molecular Biology

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Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution - Nature Structural & Molecular Biology

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