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Mechanistic insights from inflammasome structures - Nature Reviews Immunology

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Mechanistic insights from inflammasome structures - Nature Reviews Immunology

Inflammasomes are supramolecular complexes that form in the cytosol in response to pathogen-associated and damage-associated stimuli, as well as other danger signals that perturb cellular homoeostasis, resulting in host defence responses in the form of cytokine release and programmed cell death (pyroptosis). Inflammasome activity is closely associated with numerous human disorders, including rare genetic syndromes of autoinflammation, cardiovascular diseases, neurodegeneration and cancer.

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Mechanistic insights from inflammasome structures - Nature Reviews Immunology

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Mechanistic insights from inflammasome structures - Nature Reviews Immunology

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