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Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission - npj Parkinson's Disease

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Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission - npj Parkinson's Disease

The brain renin-angiotensin system (RAS) has been related to dopaminergic degeneration, and high expression of the angiotensin II (AngII) type 1 receptor (AT1) gene is a marker of the most vulnerable neurons in humans. However, it is unknown whether AngII/AT1 overactivation affects α-synuclein aggregation and transmission.

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Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission - npj Parkinson's Disease

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Angiotensin type 1 receptor activation promotes neuronal and glial alpha-synuclein aggregation and transmission - npj Parkinson's Disease

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