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Post-translational glycosylation diminishes α-synuclein pathology formation - Nature Chemical Biology

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Post-translational glycosylation diminishes α-synuclein pathology formation - Nature Chemical Biology

O-linked N-acetylglucosamine (O-GlcNAc) is an endogenous form of glycosylation that alters the structure of α-synuclein amyloid fibrils and attenuates their pathogenetic properties. The modified fibrils have a significantly reduced ability to seed the aggregation of endogenous α-synuclein in cultured neurons and in mice brains in vivo, which results in reduced pathology.

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Post-translational glycosylation diminishes α-synuclein pathology formation - Nature Chemical Biology

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Post-translational glycosylation diminishes α-synuclein pathology formation - Nature Chemical Biology

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