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Melanoma leverages local cues to promote liver-specific metastasis - Nature Cancer

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Melanoma leverages local cues to promote liver-specific metastasis - Nature Cancer

Using CRISPR–Cas9 screens, we found that cancer-cell-intrinsic loss of Pip4k2c conferred liver-metastatic organotropism in melanoma through hypersensitization to insulin-mediated PI3K–AKT signaling via co-optation of distinct hepatic metabolic cues. Additionally, we showed that combinatorial therapies that abolished physiological and drug-induced changes in glucose and insulin levels specifically reduced liver metastasis.

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Melanoma leverages local cues to promote liver-specific metastasis - Nature Cancer

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Melanoma leverages local cues to promote liver-specific metastasis - Nature Cancer

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