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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis - Nature Neuroscience

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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis - Nature Neuroscience

Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial oxidation and lipid accumulation that is dependent on prior wake and requires the Drosophila APOE orthologs NLaz and GLaz, which mediate neuron–glia lipid transfer. In turn, a full night of sleep is required for glial lipid clearance, mitochondrial oxidative recovery and maximal neuronal mitophagy.

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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis - Nature Neuroscience

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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis - Nature Neuroscience

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