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Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization - Communications Biology

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Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization - Communications Biology

At the early stage of tumor progression, fibroblasts are located at the outer edges of the tumor, forming an encasing layer around it. In this work, we have developed a 3D in vitro model where fibroblasts' layout resembles the structure seen in carcinoma in situ. We use a microfluidic encapsulation technology to co-culture fibroblasts and cancer cells within hollow, permeable, and elastic alginate shells. We

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Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization - Communications Biology

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Compressive stress triggers fibroblasts spreading over cancer cells to generate carcinoma in situ organization - Communications Biology

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