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Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer - Nature Cancer

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Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer - Nature Cancer

Our study reveals that the LGR4–Wnt signaling pathway dictates both ferroptosis and stemness traits to confer drug resistance to tumor cells. We thus generated a monoclonal antibody against LGR4 that blocks LGR4–Wnt signaling and sensitizes chemotherapy-resistant colorectal cancer tumors via selective promotion of ferroptosis.

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Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer - Nature Cancer

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Targeting LGR4–Wnt activates ferroptosis and reverses drug resistance in colorectal cancer - Nature Cancer

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