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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice - Nature Communications

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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice - Nature Communications

Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could be modulated therapeutically to prevent metastasis. Here, we show that macrophages respond to β-glucan (odetiglucan) treatment by inhibiting liver metastasis.

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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice - Nature Communications

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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice - Nature Communications

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