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Immunoengineering can overcome the glycocalyx armour of cancer cells - Nature Materials

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Immunoengineering can overcome the glycocalyx armour of cancer cells - Nature Materials

Cancer cell glycocalyx is a major line of defence against immune surveillance. However, how specific physical properties of the glycocalyx are regulated on a molecular level, contribute to immune evasion and may be overcome through immunoengineering must be resolved. Here we report how cancer-associated mucins and their glycosylation contribute to the nanoscale material thickness of the glycocalyx and consequently modulate the functional interactions with cytotoxic immune cells.

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Immunoengineering can overcome the glycocalyx armour of cancer cells - Nature Materials

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Immunoengineering can overcome the glycocalyx armour of cancer cells - Nature Materials

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