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Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression - Nature Genetics

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Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression - Nature Genetics

Clear cell renal cell carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic and spatial transcriptomic and metabolomic analyses on 100 patients with ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. Our analysis identifies four ccRCC subtypes including De-clear cell differentiated (DCCD)-ccRCC, a subtype with distinctive metabolic features.

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Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression - Nature Genetics

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Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression - Nature Genetics

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