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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition - Nature Genetics

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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition - Nature Genetics

Polycomb group proteins have a critical role in silencing transcription during development. It is commonly proposed that Polycomb-dependent changes in genome folding, which compact chromatin, contribute directly to repression by blocking the binding of activating complexes. Recently, it has also been argued that liquid–liquid demixing of Polycomb proteins facilitates this compaction and repression by phase-separating target genes into a membraneless compartment.

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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition - Nature Genetics

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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition - Nature Genetics

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