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Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection - Nature Communications

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Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection - Nature Communications

Efficient cytosolic delivery of RNA molecules remains a formidable barrier for RNA therapeutic strategies. Lipid nanoparticles (LNPs) serve as state-of-the-art carriers that can deliver RNA molecules intracellularly, as exemplified by the recent implementation of several vaccines against SARS-CoV-2. Using a bottom-up rational design approach, we assemble LNPs that contain programmable lipid phases encapsulating small interfering RNA (siRNA).

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Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection - Nature Communications

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Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection - Nature Communications

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