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NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA - Molecular Psychiatry

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NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA - Molecular Psychiatry

Major depressive disorder (MDD) is characterized by diverse debilitating symptoms that include loss of motivation and anhedonia. If multiple medications, psychotherapy, and electroconvulsive therapy fail in some patients with MDD, their condition is then termed treatment-resistant depression (TRD). MDD can be associated with abnormalities in the reward-system–dopaminergic mesolimbic pathway, in which the nucleus accumbens (NAc) and ventral tegmental area (VTA) play major roles.

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NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA - Molecular Psychiatry

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NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA - Molecular Psychiatry

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