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Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling - Nature Chemistry

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Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling - Nature Chemistry

Catalysis with engineered enzymes has provided more efficient routes for the production of active pharmaceutical agents. However, the potential of biocatalysis to assist in early-stage drug discovery campaigns remains largely untapped. In this study, we have developed a biocatalytic strategy for the construction of sp3-rich polycyclic compounds via the intramolecular cyclopropanation of benzothiophenes and related heterocycles.

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Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling - Nature Chemistry

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Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling - Nature Chemistry

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