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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal - Nature Cell Biology

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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal - Nature Cell Biology

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not only contributes to anti-viral resistance, but also causes pathogenic inflammation in many disease contexts.

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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal - Nature Cell Biology

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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal - Nature Cell Biology

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