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A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control - Nature Methods

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A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control - Nature Methods

Delivery of very small amounts of reagents to the near-field of cells with micrometer spatial precision and millisecond time resolution is currently out of reach. Here we present μkiss as a micropipette-based scheme for brushing a layer of small molecules and nanoparticles onto the live cell membrane from a subfemtoliter confined volume of a perfusion flow. We characterize our system through both experiments and modeling, and

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A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control - Nature Methods

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A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control - Nature Methods

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