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Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling - Communications Biology

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Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling - Communications Biology

Accurate mitosis is coordinated by the spindle assembly checkpoint (SAC) through the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex or cyclosome (APC/C). As an essential regulator, Cdc20 promotes mitotic exit through activating APC/C and monitors kinetochore-microtubule attachment through activating SAC. Cdc20 requires multiple interactions with APC/C and MCC subunits to elicit these functions.

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Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling - Communications Biology

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Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling - Communications Biology

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