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An oncolytic virus–T cell chimera for cancer immunotherapy - Nature Biotechnology

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An oncolytic virus–T cell chimera for cancer immunotherapy - Nature Biotechnology

The efficacy of oncolytic adenoviruses (OAs) for cancer therapy has been limited by insufficient delivery to tumors after systemic injection and the propensity of OAs to induce the expression of immune checkpoints. To address these limitations, we use T cells to deliver OAs into tumors and engineer the OA to express a Cas9 system targeting the PDL1 gene encoding the immune checkpoint protein PD-L1.

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An oncolytic virus–T cell chimera for cancer immunotherapy - Nature Biotechnology

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An oncolytic virus–T cell chimera for cancer immunotherapy - Nature Biotechnology

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