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MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma - Cell Death & Disease

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MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma - Cell Death & Disease

MYCN amplification is an independent poor prognostic factor in patients with high-risk neuroblastoma (NB). Further exploring the molecular regulatory mechanisms in MYCN-amplified NB will help to develop novel therapy targets. In this study, methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) was identified as the differentially expressed gene (DEG) highly expressed in MYCN-amplified NB, and it showed a positive correlation with MYCN and was associated with a poor prognosis of NB patients.

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MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma - Cell Death & Disease

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MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma - Cell Death & Disease

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