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Convergence of coronary artery disease genes onto endothelial cell programs - Nature

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Convergence of coronary artery disease genes onto endothelial cell programs - Nature

Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge1–3. For some diseases, a successful strategy has been to look for cases in which multiple GWAS loci contain genes that act in the same biological pathway1–6. However, our knowledge of which genes act in which pathways is incomplete, particularly for cell-type-specific pathways or understudied genes. Here we introduce a method to connect GWAS variants to functions.

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Convergence of coronary artery disease genes onto endothelial cell programs - Nature

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Convergence of coronary artery disease genes onto endothelial cell programs - Nature

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