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Translation selectively destroys non-functional transcription complexes - Nature

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Translation selectively destroys non-functional transcription complexes - Nature

Transcription elongation stalls at lesions in the DNA template1. For the DNA lesion to be repaired, the stalled transcription elongation complex (EC) has to be removed from the damaged site2. Here we show that translation, which is coupled to transcription in bacteria, actively dislodges stalled ECs from the damaged DNA template. By contrast, paused, but otherwise elongation-competent, ECs are not dislodged by the ribosome. Instead, they are helped back into processive elongation.

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Translation selectively destroys non-functional transcription complexes - Nature

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Translation selectively destroys non-functional transcription complexes - Nature

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