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Bile salt hydrolase catalyses formation of amine-conjugated bile acids - Nature

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids - Nature

Bacteria in the gastrointestinal tract produce amino acid bile acid amidates that can affect host-mediated metabolic processes1–6; however, the bacterial gene(s) responsible for their production remain unknown. Herein, we report that bile salt hydrolase (BSH) possesses dual functions in bile acid metabolism. Specifically, we identified a previously unknown role for BSH as an amine N-acyltransferase that conjugates amines to bile acids, thus forming bacterial bile acid amidates (BBAAs).

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids - Nature

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids - Nature

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