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Bile salt hydrolase acyltransferase activity expands bile acid diversity - Nature

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Bile salt hydrolase acyltransferase activity expands bile acid diversity - Nature

Bile acids (BAs) are steroid detergents in bile that contribute to the absorption of fats and fat-soluble vitamins while shaping the gut microbiome because of their antimicrobial properties1–4. Here we identify the enzyme responsible for a mechanism of BA metabolism by the gut microbiota involving amino acid conjugation to the acyl-site of BAs, thus producing a diverse suite of microbially conjugated bile acids (MCBAs).

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Bile salt hydrolase acyltransferase activity expands bile acid diversity - Nature

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Bile salt hydrolase acyltransferase activity expands bile acid diversity - Nature

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