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ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models - Cell Death & Differentiation

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ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models - Cell Death & Differentiation

Pancreatic β-cell failure by WFS1 deficiency is manifested in individuals with wolfram syndrome (WS). The lack of a suitable human model in WS has impeded progress in the development of new treatments. Here, human pluripotent stem cell derived pancreatic islets (SC-islets) harboring WFS1 deficiency and mouse model of β cell specific Wfs1 knockout were applied to model β-cell failure in WS.

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ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models - Cell Death & Differentiation

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ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models - Cell Death & Differentiation

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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