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Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair - Nature Structural & Molecular Biology

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Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair - Nature Structural & Molecular Biology

During transcription-coupled DNA repair (TCR), RNA polymerase II (Pol II) transitions from a transcriptionally active state to an arrested state that allows for removal of DNA lesions. This transition requires site-specific ubiquitylation of Pol II by the CRL4CSA ubiquitin ligase, a process that is facilitated by ELOF1 in an unknown way.

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Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair - Nature Structural & Molecular Biology

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Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair - Nature Structural & Molecular Biology

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