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3 months ago

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State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia - Leukemia

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State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia - Leukemia

Chronic myeloid leukemia (CML) is initiated and maintained by BCR | ABL which is clinically targeted using tyrosine kinase inhibitors (TKIs). TKIs can induce long-term remission but are also not curative. Thus, CML is an ideal system to test our hypothesis that transcriptome-based state-transition models accurately predict cancer evolution and treatment response. We collected time-sequential blood samples from tetracycline-off (Tet-Off) BCR | ABL-inducible transgenic mice and wild-type controls.

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State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia - Leukemia

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State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia - Leukemia

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